Pyridyl Organozincs and Grignards

New practical synthetic approaches for introducing a pyridine ring into complex organic molecules are of high value. Based on a paper published in conjunction with Rieke Metals in 2010 (Molecules 2010,15, 8006-8038; doi:10.3390/molecules15118006) heterocyclic compounds which contain a pyridine function have been frequently found in natural products that have biological activity, especially in pharmaceutical, agrochemical and medicinal chemistry [5-7]. There are also a number of pyridine derivatives that have been used in material chemistry [8,9].

In material science 3-Substituted thiophene derivatives have been utilized for the preparation of useful compounds in both materials and pharmaceutical science. For instance, poly(3-alkyl thiophene) films have good processability potential [48-52] and have been found to be stable for extended periods under a variety of conditions. More interestingly, 3-substituted thiophene derivatives have been found to be topical carbonic anhydrase inhibitors [53].

In life science a practical synthetic route for the preparation of 2-pyridyl and 3-pyridyl derivatives has been accomplished by utilizing a simple coupling reaction of a stable 2-pyridylzinc bromides and 3-pyridylzinc bromides, which were prepared via the direct insertion of active zinc to the corresponding bromopyridines. The subsequent coupling reactions with a variety of different electrophiles have been carried out under mild conditions affording the coupling products.

Rieke Metals offers several analogs of pyridyl organozincs and grignards as well as bypyridine compounds with the capability to offer several others. You can visit us at www.riekemetals.com and check out our 2000, 3000, 10000 and 11000 series of products.